Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.50 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | CD38 | P28907 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 9/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26921049 | 1.00 | RPS6KB1 (0.50) | RPS6KB1AURKACD38CTSLCTSB | |
| SCHEMBL26923623 | 0.87 | VNN1 (0.43) | CD38CTSLCTSB | |
| SCHEMBL26921856 | 0.86 | RPS6KB1 (0.48) | RPS6KB1AURKACD38AURKBSTAT6 | |
| SCHEMBL29834798 | 0.86 | RPS6KB1 (0.48) | RPS6KB1AURKACD38AURKBSTAT6 | |
| SCHEMBL26922228 | 0.84 | RPS6KB1 (0.46) | RPS6KB1AURKASTAT6 | |
| SCHEMBL26923148 | 0.83 | JAK3 (0.42) | RPS6KB1AURKACTSLCTSB | |
| SCHEMBL26922757 | 0.82 | RPS6KB1 (0.46) | RPS6KB1AURKASTAT6 | |
| SCHEMBL29834922 | 0.81 | CTSL (0.46) | RPS6KB1AURKACTSLCTSBAURKB | |
| SCHEMBL26922340 | 0.81 | CTSL (0.46) | RPS6KB1AURKACTSLCTSBAURKB | |
| SCHEMBL26921986 | 0.81 | AURKA (0.51) | RPS6KB1AURKACD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288539-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | Research Institute at Nationwide Children's Hospital (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169922-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2022-08-11 | — | — | WO | disclosed |