Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26925369 | 1.00 | LCK (0.39) | LCKHTR3AGRM4HTR2CSLC6A4 | |
| SCHEMBL30705890 | 0.92 | HTR6 (0.44) | LCKBCHEHTR6IRAK1 | |
| SCHEMBL30706180 | 0.92 | HTR6 (0.44) | LCKBCHEHTR6IRAK1 | |
| SCHEMBL30794350 | 0.88 | PRMT5 (0.42) | CYP2D6CYP2C9GRIN2BBCHEHTR6 | |
| SCHEMBL30794025 | 0.88 | PRMT5 (0.42) | CYP2D6CYP2C9GRIN2BBCHEHTR6 | |
| SCHEMBL30794352 | 0.88 | PRMT5 (0.42) | CYP2D6CYP2C9GRIN2BBCHEHTR6 | |
| SCHEMBL30706001 | 0.85 | HTR6 (0.42) | CYP2C9BCHEHTR6IRAK1 | |
| SCHEMBL26637161 | 0.85 | HTR3A (0.38) | HTR3ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL26635645 | 0.85 | HTR3A (0.38) | HTR3ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL26635642 | 0.85 | HTR3A (0.38) | HTR3ACHRNB2CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023244918-A1 | QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |
| WO-2023240038-A1 | TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-12-14 | — | — | WO | disclosed |