SCHEMBL26934239

SCHEMBL26934239

O=C(O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)Nc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.51
CRHR2 Q13324 1/20 0.51
MME P08473 3/20 0.47
MAPT P10636 2/20 0.46
ALDH1A1 P00352 2/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
GAA P10253 1/20 0.45
ITGA4 P13612 1/20 0.44
ITGB7 P26010 1/20 0.44
CA2 P00918 1/20 0.44
PKM P14618 1/20 0.44
NPC1 O15118 1/20 0.44
TP53 P04637 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
KDM4A O75164 1/20 0.44
ACE P12821 2/20 0.44
CPA1 P15085 2/20 0.44
ACE2 Q9BYF1 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26934235 1.00 CRHBP (0.51) CRHBPCRHR2MMEMAPTALDH1A1
SCHEMBL1333936 0.92 CRHBP (0.56) CRHBPCRHR2MAPTALDH1A1MEN1
SCHEMBL1333933 0.92 CRHBP (0.56) CRHBPCRHR2MAPTALDH1A1MEN1
SCHEMBL26934218 0.92 MME (0.51) CRHBPCRHR2MMEITGA4ITGB7
SCHEMBL26934199 0.92 CRHBP (0.51) CRHBPCRHR2MMEACECPA1
SCHEMBL26934226 0.92 MME (0.51) CRHBPCRHR2MMEITGA4ITGB7
SCHEMBL26934210 0.92 CRHBP (0.51) CRHBPCRHR2MMEACECPA1
SCHEMBL26934214 0.90 CRHBP (0.54) CRHBPCRHR2MMEMAPTALDH1A1
SCHEMBL26934216 0.90 CRHBP (0.54) CRHBPCRHR2MMEMAPTALDH1A1
SCHEMBL26934201 0.90 CRHBP (0.54) CRHBPCRHR2MMEMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11845708-B2 Method for photocleavage of amide bonds NANJING TECH UNIVERSITY (CN) 2023-12-19 US disclosed
US-20220289665-A1 METHOD FOR PHOTOCLEAVAGE OF AMIDE BONDS NANJING TECH UNIVERSITY (CN) 2022-09-15 US disclosed
CN-113024397-A Method for photocleavage of amido bond 南京工业大学 2021-06-25 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220289665-A1 METHOD FOR PHOTOCLEAVAGE OF AMIDE BONDS DNPEP, ASPH, ALDH7A1 CRHBP 598/4885CRHR2 156/4885MME 1031/4885
US-11845708-B2 Method for photocleavage of amide bonds DNPEP, ASPH, ALDH7A1 CRHBP 598/4885CRHR2 156/4885MME 1031/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.