Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
| ▸ | GPR139 | Q6DWJ6 | 15/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2695127 | 1.00 | TRPV1 (0.59) | TRPV1GPR139MAPK1ENPP2AR | |
| SCHEMBL14291771 | 0.91 | TRPV1 (0.58) | TRPV1GPR139MAPK1ENPP2AR | |
| SCHEMBL2692974 | 0.91 | TRPV1 (0.68) | TRPV1GPR139MAPK1ENPP2AR | |
| SCHEMBL306502 | 0.89 | TRPV1 (0.58) | TRPV1GPR139MAPK1ENPP2AR | |
| SCHEMBL308305 | 0.89 | TRPV1 (0.58) | TRPV1GPR139MAPK1ENPP2AR | |
| SCHEMBL29454367 | 0.89 | TRPV1 (0.58) | TRPV1GPR139MAPK1ENPP2AR | |
| SCHEMBL306501 | 0.89 | TRPV1 (0.58) | TRPV1GPR139MAPK1ENPP2AR | |
| SCHEMBL2692682 | 0.89 | TRPV1 (0.53) | TRPV1GPR139MAPK1ENPP2 | |
| SCHEMBL2692194 | 0.89 | TRPV1 (0.51) | TRPV1GPR139MAPK1AR | |
| Hydrochloric Acid SCHEMBL29454378 | 0.89 | TRPV1 (0.57) | TRPV1GPR139MAPK1ENPP2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168668-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-05-01 | — | — | US | claimed |
| EP-1966156-B1 | NEW COMPOUNDS III | ASTRAZENECA AB (SE) | 2011-12-21 | — | — | EP | claimed |
| US-20100286202-A1 | New Compounds | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | US | claimed |
| US-20080171770-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | claimed |
| US-8168668-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-05-01 | — | — | US | disclosed |
| EP-1966156-B1 | NEW COMPOUNDS III | ASTRAZENECA AB (SE) | 2011-12-21 | — | — | EP | disclosed |
| US-20100286202-A1 | New Compounds | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | US | disclosed |
| US-7618993-B2 | Compounds | ASTRAZENECA AB (SE) | 2009-11-17 | — | — | US | disclosed |
| US-20080171770-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286202-A1 | New Compounds | REN, PCSK9, FURIN | TRPV1 117/4885GPR139 1736/4885MAPK1 3756/4885 |
| US-20080171770-A1 | Compounds | REN, PCSK9, SLC10A1 | TRPV1 91/4885GPR139 2831/4885MAPK1 3790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.