Citric Acid

Citric Acid

SCHEMBL26949

O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])O.[Na+]

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.38
ALDH1A1 P00352 2/20 0.79
CA4 P22748 1/20 0.44
HMGCR P04035 1/20 0.42
CHRM1 P11229 1/20 0.42
TBXA2R P21731 1/20 0.42
ADRA1A P35348 1/20 0.42
TSHR P16473 2/20 0.40
CYP2D6 P10635 2/20 0.40
CYP2C19 P33261 1/20 0.40
HIF1A Q16665 1/20 0.40
KDM4E B2RXH2 2/20 0.40
LMNA P02545 2/20 0.40
MAPT P10636 1/20 0.40
ALOX15 P16050 1/20 0.40
ACLY P53396 4/20 0.39
SLC13A5 Q86YT5 4/20 0.39
CPT2 P23786 1/20 0.38
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL27925300 1.00 ALDH1A1 (0.79) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL6657507 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL2701972 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL8647305 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL29089410 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL25331832 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL8032258 0.95 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL735448 0.95 ALDH1A1 (0.79) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL21372603 0.95 ALDH1A1 (0.79) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL3766978 0.95 ALDH1A1 (0.79) ALDH1A1CA4HMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1658 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12012495-B1 3-D printable expendable lost foam pattern BRUNSWICK CORPORATION (US) 2024-06-18 US claimed
CN-116285628-B Preparation method of pipeline steel-based underwater cooperative self-repairing super-hydrophobic coating 山东科技大学 2024-02-02 CN claimed
CN-116617866-B Preparation method of high-porosity polyphenylene sulfide filtering membrane 阿克菲姆膜材(嘉兴)有限公司 2023-11-28 CN claimed
CN-117084975-A Urapidil hydrochloride injection 石家庄四药有限公司 2023-11-21 CN claimed
EP-4273201-A2 THERMALLY ACTIVATABLE EXPANSION ELEMENT, USE THEREOF, AND JOINT PART AND COMPOSITE COMPONENT COMPRISING THE THERMALLY ACTIVATABLE EXPANSION ELEMENT Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2023-11-08 EP claimed
CN-116617866-A Preparation method of high-porosity polyphenylene sulfide filtering membrane 阿克菲姆膜材(嘉兴)有限公司 2023-08-22 CN claimed
CN-116285628-A Preparation method of pipeline steel-based underwater cooperative self-repairing super-hydrophobic coating 山东科技大学 2023-06-23 CN claimed
CN-115645360-A Urapidil hydrochloride injection 石家庄四药有限公司 2023-01-31 CN claimed
CN-114794159-A Composition containing camellia saponin as main component for preventing and treating Chinese rose diseases and preparation method thereof 湖南省林业科学院 2022-07-29 CN claimed
CN-114685842-A Conductive polybutylene foam material and preparation method thereof 黄河三角洲京博化工研究院有限公司 2022-07-01 CN claimed
US-5429822-A Capsule covered with polymeric membrane, polylactides CAMBRIDGE SCIENTIFIC, INC. (US) 1995-07-04 US claimed
EP-0520028-B1 POLYPROPYLENE FOAM SHEETS JAMES RIVER CORP (US) 1995-05-17 EP claimed
EP-0641219-A1 BIODEGRADABLE BURSTING RELEASE SYSTEM CAMBRIDGE SCIENTIFIC, INC. (US) 1995-03-08 EP claimed
WO-1994024209-A1 FIRE-RESISTANT ESSENTIALLY HALOGEN-FREE EPOXY COMPOSITION MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-10-27 WO claimed
WO-1993017704-A1 BIODEGRADABLE BURSTING RELEASE SYSTEM CAMBRIDGE SCIENTIFIC, INC. (US) 1993-09-16 WO claimed
US-5124098-A Mixing alkali metal bicarbonate and citric acid blowing agents with polyester and polycarbonate, spinning, expansion HOECHST AKTIENGESELLSCHAFT (DE) 1992-06-23 US claimed
EP-0203741-B1 METHOD AND PRODUCT FOR REMOVAL OF CHLORAMINES, CHLORINE AND AMMONIA FROM AQUACULTURE WATER AQUASCIENCE RESEARCH GROUP, INC. (US) 1990-02-28 EP claimed
EP-0288633-A2 Odour control AQUASCIENCE RESEARCH GROUP, INC. (US) 1988-11-02 EP claimed
US-4666610-A Method and product for removal of chloramines, chlorine and ammonia from aquaculture water AQUASCIENCE RESEARCH GROUP, INC. (US) 1987-05-19 US claimed
EP-0203741-A2 Method and product for removal of chloramines, chlorine and ammonia from aquaculture water AQUASCIENCE RESEARCH GROUP, INC. (US) 1986-12-03 EP claimed