Citric Acid

Citric Acid

SCHEMBL735448

O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])[O-].[Na+].[Na+]

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.38
ALDH1A1 P00352 2/20 0.79
CA4 P22748 1/20 0.44
HMGCR P04035 1/20 0.42
CHRM1 P11229 1/20 0.42
TBXA2R P21731 1/20 0.42
ADRA1A P35348 1/20 0.42
TSHR P16473 2/20 0.40
CYP2D6 P10635 2/20 0.40
CYP2C19 P33261 1/20 0.40
HIF1A Q16665 1/20 0.40
KDM4E B2RXH2 2/20 0.40
LMNA P02545 2/20 0.40
MAPT P10636 1/20 0.40
ALOX15 P16050 1/20 0.40
ACLY P53396 4/20 0.39
SLC13A5 Q86YT5 4/20 0.39
CPT2 P23786 1/20 0.38
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL10561739 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL9293104 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL8647305 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL25332361 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL1932644 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL25331832 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL3942871 0.97 ALDH1A1 (0.75) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL8032258 0.95 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL5030701 0.95 ALDH1A1 (0.79) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL673949 0.95 ALDH1A1 (0.79) ALDH1A1CA4HMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111537505-B Method for evaluating disastrous rainfall encountered in wheat harvesting period 邯郸市农业科学院 2022-06-28 CN claimed
CN-111537505-A Method for evaluating disastrous rainfall encountered during wheat harvesting period 邯郸市农业科学院 2020-08-14 CN claimed
CN-108174855-A A kind of non-corrosive chlorine-containing disinfecting effervescent tablet 北京长江脉医药科技有限责任公司 2018-06-19 CN claimed
CN-104861601-A Edible grease removal towel and preparation method thereof ZHEJIANG KINLEAD INNOVATIVE MATERIALS CO LTD 2015-08-26 CN claimed
EP-1802277-B1 LIPOSOMAL COMPOSITION COMPRISING AN ACTIVE INGREDIENT FOR RELAXING SMOOTH MUSCLEs AND THERAPEUTIC USE OF SAID COMPOSITION POLYMUN SCIENT IMMUNBIO FORSCH (AT) 2010-01-13 EP claimed
US-5629024-A Method of forming an iodine based germicide composition SYMBOLLON CORPORATION (US) 1997-05-13 US claimed
EP-0290296-B1 Liposomal formulations with a high antineoplastic agent/lipid ratio LIPOSOME CO INC (US) 1996-05-08 EP claimed
EP-0290296-A2 Liposomal formulations with a high antineoplastic agent/lipid ratio THE LIPOSOME COMPANY, INC. (US) 1988-11-09 EP claimed
WO-1988006442-A1 HIGH DRUG:LIPID FORMULATIONS OF LIPOSOMAL-ANTINEOPLASTIC AGENTS THE LIPOSOME COMPANY, INC. (US) 1988-09-07 WO claimed
EP-4223313-A1 PHARMACEUTICAL COMPOSITION COMPRISING ACID-BASE NEUTRALIZATION COMBINATION AND APPLICATION THEREOF Chengdu Kuachangaopu Medical Technology Co., Ltd. (CN) 2023-08-09 EP disclosed
CN-111537505-B Method for evaluating disastrous rainfall encountered in wheat harvesting period 邯郸市农业科学院 2022-06-28 CN disclosed
CN-105126082-B Polypeptide medicinal preparation and preparation method thereof 齐鲁制药有限公司 2022-03-04 CN disclosed
US-20220061641-A1 APPARATUS FOR THERMALLY STABLE BALLOON EXPANSION CAPSOVISION INC. 2022-03-03 US disclosed
EP-3927801-A1 STABLE ANHYDROUS FOAMING AND GELLING HAND SOAP CONCENTRATE AND METHOD OF MAKING SAME One Home Brands, Inc. (US) 2021-12-29 EP disclosed
EP-0290296-A2 Liposomal formulations with a high antineoplastic agent/lipid ratio THE LIPOSOME COMPANY, INC. (US) 1988-11-09 EP disclosed
WO-1988006442-A1 HIGH DRUG:LIPID FORMULATIONS OF LIPOSOMAL-ANTINEOPLASTIC AGENTS THE LIPOSOME COMPANY, INC. (US) 1988-09-07 WO disclosed
EP-0279125-A1 Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them BEECHAM - WUELFING GmbH & Co. KG (DE) 1988-08-24 EP disclosed
US-4118517-A SLURRYING, SPRAY-DRYING SNOW BRAND MILK PRODUCTS CO. LTD. (JP) 1978-10-03 US disclosed
US-4028262-A Citrate-carbonate built detergent COLGATE-PALMOLIVE COMPANY (US) 1977-06-07 US disclosed
US-4018620-A IN WATER, CALCIUM CHLORIDE AND HYDROCHLORIC ACID BIOCEL CORPORATION (US) 1977-04-19 US disclosed