Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31734939 | 1.00 | LRRK2 (0.38) | LRRK2AAK1CCNKCDK12ROCK2 | |
| SCHEMBL31734963 | 0.81 | LRRK2 (0.54) | LRRK2ROCK2CDK2CDK9CDK5 | |
| SCHEMBL26953050 | 0.81 | LRRK2 (0.54) | LRRK2ROCK2CDK2CDK9CDK5 | |
| SCHEMBL26953081 | 0.78 | PRKCI (0.48) | LRRK2CCNKCDK12JAK2CDK9 | |
| SCHEMBL31734994 | 0.78 | PRKCI (0.48) | LRRK2CCNKCDK12JAK2CDK9 | |
| SCHEMBL26953119 | 0.76 | LRRK2 (0.42) | LRRK2CCNKCDK12ROCK2TRPA1 | |
| SCHEMBL14907823 | 0.74 | LOXL2 (0.47) | LRRK2ROCK2LOXL2TRPA1JAK2 | |
| SCHEMBL26953435 | 0.70 | SGK1 (0.44) | LRRK2ROCK2LOXL2JAK2CDK2 | |
| SCHEMBL31734984 | 0.70 | SGK1 (0.44) | LRRK2ROCK2LOXL2JAK2CDK2 | |
| SCHEMBL31734915 | 0.69 | HTR2A (0.34) | CCNKCDK12ROCK2JAK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239727-A1 | LATS INHIBITORS AND USES THEREOF | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2023-12-14 | — | — | WO | disclosed |