Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.59 |
| ▸ | STK4 | Q13043 | 2/20 | 0.49 |
| ▸ | STK3 | Q13188 | 2/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31735005 | 1.00 | LRRK2 (0.59) | LRRK2STK4STK3SGK1BRAF | |
| SCHEMBL31735012 | 0.87 | SGK1 (0.57) | LRRK2STK4STK3SGK1BRAF | |
| SCHEMBL26953278 | 0.87 | SGK1 (0.57) | LRRK2STK4STK3SGK1BRAF | |
| SCHEMBL31734890 | 0.86 | LRRK2 (0.59) | LRRK2STK4STK3SGK1 | |
| SCHEMBL26953245 | 0.86 | CDK2 (0.53) | LRRK2STK4STK3SGK1BRAF | |
| SCHEMBL31734958 | 0.86 | CDK2 (0.53) | LRRK2STK4STK3SGK1BRAF | |
| SCHEMBL26953145 | 0.86 | LRRK2 (0.59) | LRRK2STK4STK3SGK1 | |
| SCHEMBL31734861 | 0.83 | CYP2A6 (0.55) | LRRK2STK3SGK1JAK3CDK2 | |
| SCHEMBL31735009 | 0.83 | LRRK2 (0.52) | LRRK2STK4STK3SGK1BRAF | |
| SCHEMBL26953146 | 0.83 | LRRK2 (0.52) | LRRK2STK4STK3SGK1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239727-A1 | LATS INHIBITORS AND USES THEREOF | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2023-12-14 | — | — | WO | disclosed |