Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 1/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.53 |
| ▸ | CDC7 | O00311 | 6/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.46 |
| ▸ | PRKACA | P17612 | 6/20 | 0.46 |
| ▸ | CLK2 | P49760 | 6/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | STK3 | Q13188 | 6/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.46 |
| ▸ | GSK3A | P49840 | 5/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | MARK3 | P27448 | 5/20 | 0.46 |
| ▸ | MELK | Q14680 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31735012 | 1.00 | SGK1 (0.57) | SGK1LRRK2CDC7ALKPRKD3 | |
| SCHEMBL26953243 | 0.90 | CYP2A6 (0.55) | SGK1LRRK2CDC7PRKD3MAP4K4 | |
| SCHEMBL31734861 | 0.90 | CYP2A6 (0.55) | SGK1LRRK2CDC7PRKD3MAP4K4 | |
| SCHEMBL26953219 | 0.88 | LRRK2 (0.45) | SGK1LRRK2CDC7PRKD3MAP4K4 | |
| SCHEMBL31735137 | 0.88 | LRRK2 (0.45) | SGK1LRRK2CDC7PRKD3MAP4K4 | |
| SCHEMBL31734890 | 0.87 | LRRK2 (0.59) | SGK1LRRK2STK3FYNTAAR1 | |
| SCHEMBL31735005 | 0.87 | LRRK2 (0.59) | SGK1LRRK2STK3CDK2JAK3 | |
| SCHEMBL26953170 | 0.87 | LRRK2 (0.59) | SGK1LRRK2STK3CDK2JAK3 | |
| SCHEMBL31734958 | 0.87 | CDK2 (0.53) | SGK1LRRK2CDC7MAP4K4PRKACA | |
| SCHEMBL26953145 | 0.87 | LRRK2 (0.59) | SGK1LRRK2STK3FYNTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239727-A1 | LATS INHIBITORS AND USES THEREOF | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2023-12-14 | — | — | WO | disclosed |