Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL980633 | 0.86 | PDPK1 (1.00) | PDPK1PTGS2PTGS1CYP2C9CYP3A4 | |
| SCHEMBL8292452 | 0.86 | PTGS2 (0.86) | PDPK1PTGS2PTGS1CYP2C9CYP1A2 | |
| SCHEMBL5674301 | 0.85 | PDPK1 (0.72) | PDPK1PTGS2PTGS1CYP2C9 | |
| SCHEMBL2694814 | 0.84 | PTGS2 (0.61) | PDPK1PTGS2PTGS1CYP2C9CYP1A2 | |
| SCHEMBL2697564 | 0.84 | PTGS2 (0.65) | PDPK1PTGS2PTGS1CYP2C9CYP1A2 | |
| SCHEMBL2698009 | 0.84 | PDPK1 (0.73) | PDPK1PTGS2PTGS1CYP2C9CYP1A2 | |
| SCHEMBL18448102 | 0.82 | PTGS2 (0.72) | PDPK1PTGS2PTGS1CYP2C9CYP3A4 | |
| SCHEMBL14747609 | 0.81 | PTGS2 (0.74) | PDPK1PTGS2PTGS1CYP2C9CYP3A4 | |
| SCHEMBL12213580 | 0.81 | PDPK1 (0.73) | PDPK1PTGS2PTGS1CYP2C9 | |
| SCHEMBL2698251 | 0.81 | PTGS1 (0.76) | PDPK1PTGS2PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580827-B2 | Anti-Francisella agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2246332-B1 | Pyrazole derivatives as anti-francisella agents | UNIV OHIO STATE RES FOUND (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20130005788-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-01-03 | — | — | US | disclosed |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
| EP-2246332-A1 | Pyrazole derivatives as anti-francisella agents | The Ohio State University Research Foundation (US) | 2010-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005788-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | PDPK1 2901/4885PTGS2 2/4885PTGS1 1/4885 |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | PDPK1 2901/4885PTGS2 2/4885PTGS1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.