Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.74 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3276806 | 0.97 | PTGS1 (0.79) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL29503530 | 0.95 | PTGS1 (0.79) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL17077240 | 0.90 | PTGS1 (0.80) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL22289006 | 0.89 | PTGS1 (0.71) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL2697786 | 0.89 | PTGS1 (0.78) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL18448495 | 0.89 | PTGS1 (1.00) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL31543731 | 0.88 | PTGS1 (0.80) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL5430134 | 0.88 | PTGS1 (0.80) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL5698545 | 0.88 | PTGS1 (0.80) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL6013922 | 0.85 | PTGS2 (1.00) | PTGS1PTGS2PDPK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580827-B2 | Anti-Francisella agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2246332-B1 | Pyrazole derivatives as anti-francisella agents | UNIV OHIO STATE RES FOUND (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20130005788-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-01-03 | — | — | US | disclosed |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
| EP-2246332-A1 | Pyrazole derivatives as anti-francisella agents | The Ohio State University Research Foundation (US) | 2010-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005788-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | PTGS1 1/4885PTGS2 2/4885PDPK1 2901/4885 |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | PTGS1 1/4885PTGS2 2/4885PDPK1 2901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.