Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | CDC25B | P30305 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.44 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26147200 | 1.00 | NR4A1 (0.55) | NR4A1NR4A2NR4A3CDC25BMMP3 | |
| SCHEMBL2695931 | 1.00 | NR4A1 (0.55) | NR4A1NR4A2NR4A3CDC25BMMP3 | |
| SCHEMBL27639968 | 0.80 | NR4A1 (0.50) | NR4A1NR4A2NR4A3CDC25BMMP3 | |
| SCHEMBL26147592 | 0.79 | NR4A1 (0.58) | NR4A1NR4A2NR4A3CDC25BMMP3 | |
| SCHEMBL2697713 | 0.79 | KMT2A (0.53) | NR4A1NR4A2NR4A3HDAC8CYP1A2 | |
| SCHEMBL2697711 | 0.79 | KMT2A (0.53) | NR4A1NR4A2NR4A3HDAC8CYP1A2 | |
| SCHEMBL2695419 | 0.78 | PLA2G2D (0.47) | CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2D | |
| SCHEMBL2695416 | 0.78 | PLA2G2D (0.47) | CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2D | |
| SCHEMBL12063071 | 0.77 | ALDH1A1 (0.53) | CYP1A2CYP3A4CYP2C19PTPN1PLA2G2D | |
| SCHEMBL979869 | 0.77 | ALDH1A1 (0.53) | CYP1A2CYP3A4CYP2C19PTPN1PLA2G2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580827-B2 | Anti-Francisella agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2246332-B1 | Pyrazole derivatives as anti-francisella agents | UNIV OHIO STATE RES FOUND (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20130005788-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-01-03 | — | — | US | disclosed |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
| EP-2246332-A1 | Pyrazole derivatives as anti-francisella agents | The Ohio State University Research Foundation (US) | 2010-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005788-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | NR4A1 3642/4885NR4A2 3704/4885NR4A3 4014/4885 |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | NR4A1 3642/4885NR4A2 3704/4885NR4A3 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.