Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10192131 | 0.94 | HRH3 (0.42) | HRH3 | |
| SCHEMBL26972454 | 0.93 | HRH3 (0.41) | HRH3MAOB | |
| SCHEMBL21667849 | 0.91 | HRH3 (0.45) | HRH3MAOBCYP2D6 | |
| SCHEMBL823898 | 0.91 | HRH3 (0.49) | HRH3MAOBCYP2D6 | |
| SCHEMBL24621966 | 0.90 | HRH3 (0.35) | HRH3MAOBCYP3A4CYP2D6 | |
| SCHEMBL21472754 | 0.90 | HRH3 (0.36) | HRH3MAOB | |
| SCHEMBL10025515 | 0.89 | HRH3 (0.51) | HRH3MAOB | |
| SCHEMBL1106451 | 0.89 | HRH3 (0.51) | HRH3MAOB | |
| SCHEMBL22560529 | 0.88 | ALDH1A1 (0.38) | HRH3 | |
| SCHEMBL20314590 | 0.88 | HRH3 (0.35) | HRH3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858940-B2 | Selective modulators of mutant LRRK2 proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858940-B2 | Selective modulators of mutant LRRK2 proteolysis and associated methods of use | LRRK2, ADRM1, CRBN | HRH3 2096/4885MAOB 1845/4885CYP3A4 4784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.