Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30068156 | 0.87 | MTOR (0.40) | SMN1; SMN2LMNAALDH1A1HPGDHTT | |
| SCHEMBL26646921 | 0.87 | MTOR (0.40) | SMN1; SMN2LMNAALDH1A1HPGDHTT | |
| SCHEMBL26975133 | 0.78 | SLC29A1 (0.40) | LMNAALDH1A1HPGDHTTPDE10A | |
| SCHEMBL26975132 | 0.71 | ALDH1A1 (0.44) | SMN1; SMN2LMNAALDH1A1HPGDHTT | |
| SCHEMBL26975121 | 0.70 | SRC (0.44) | SMN1; SMN2LMNAALDH1A1HPGDHTT | |
| SCHEMBL13828583 | 0.70 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1HPGDMAPTPDE10A | |
| SCHEMBL16036853 | 0.69 | PIK3R1 (0.48) | SMN1; SMN2ALDH1A1HPGDMAPTPDE10A | |
| SCHEMBL23773549 | 0.68 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTPDE10AKMT2A | |
| SCHEMBL10621985 | 0.68 | NUDT1 (0.55) | LMNAMAPTPDE10AKDM4ENUDT1 | |
| SCHEMBL26647453 | 0.68 | MTOR (0.46) | SMN1; SMN2LMNAALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858915-B2 | Polo like kinase 4 inhibitors | ORIC PHARMACEUTICALS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858915-B2 | Polo like kinase 4 inhibitors | PLK4, PLK2, PLK3 | SMN1; SMN2 2786/4885LMNA 2193/4885ALDH1A1 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.