SCHEMBL26987992

SCHEMBL26987992

O=C(c1ccccc1)c1cnc(Cl)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.58
VNN1 O95497 11/20 0.54
KMT2A Q03164 2/20 0.52
MEN1 O00255 1/20 0.52
ATM Q13315 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
SRD5A2 P31213 1/20 0.50
ALOX15 P16050 1/20 0.46
HTT P42858 1/20 0.46
NPC1 O15118 1/20 0.45
NFKB1 P19838 1/20 0.45
PPARG P37231 1/20 0.45
RAB9A P51151 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45
NCOA2 Q15596 1/20 0.45
NCOA1 Q15788 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
NCOA3 Q9Y6Q9 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28226889 0.81 ALDH1A1 (0.61) ALDH1A1VNN1KMT2AMEN1ATM
SCHEMBL25981388 0.80 NPC1 (0.59) ALDH1A1VNN1NPC1RAB9ASMN1; SMN2
SCHEMBL31473447 0.80 NAPRT (0.66) ALDH1A1VNN1KMT2AMEN1ATM
SCHEMBL3383611 0.80 NAPRT (0.66) ALDH1A1VNN1KMT2AMEN1ATM
SCHEMBL11457022 0.79 ALDH1A1 (0.58) ALDH1A1VNN1KMT2AMEN1ATM
SCHEMBL28226892 0.79 ALDH1A1 (0.58) ALDH1A1VNN1KMT2AMEN1ATM
Benzophenone SCHEMBL8440806 0.79 ALDH1A1 (0.93) ALDH1A1KMT2AMEN1ATMTDP1
SCHEMBL18286226 0.78 VNN1 (0.58) ALDH1A1VNN1KMT2AMEN1HTT
SCHEMBL7916225 0.77 ALDH1A1 (0.50) ALDH1A1VNN1KMT2AMEN1ATM
Hydrochloric Acid SCHEMBL7478603 0.77 NAPRT (0.61) ALDH1A1VNN1KMT2AMEN1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024008909-A1 INHIBITORS OF CORONAVIRUS JANSSEN PHARMACEUTICA NV (BE) 2024-01-11 WO disclosed