Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26988027 | 1.00 | VNN1 (0.33) | VNN1CYP3A4CYP2D6EPHX2GRM5 | |
| SCHEMBL26987866 | 0.81 | VNN1 (0.43) | VNN1CYP3A4CYP2D6EPHX2KMT2A | |
| SCHEMBL2890195 | 0.81 | VNN1 (0.43) | VNN1CYP3A4CYP2D6EPHX2KMT2A | |
| SCHEMBL2327112 | 0.80 | KDM1A (0.31) | KMT2A | |
| SCHEMBL21359037 | 0.78 | VNN1 (0.34) | VNN1CYP3A4CYP2D6EPHX2GRM5 | |
| SCHEMBL12284806 | 0.77 | CYP2D6 (0.39) | CYP3A4CYP2D6KMT2A | |
| SCHEMBL15716997 | 0.75 | USP2 (0.36) | VNN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL15516069 | 0.73 | ALDH1A1 (0.44) | CYP3A4EPHX2GRM5KMT2A | |
| SCHEMBL25237543 | 0.71 | CYP1A2 (0.33) | VNN1CYP3A4CYP2D6DPP4 | |
| SCHEMBL346211 | 0.70 | JAK2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024218686-A1 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2024-10-24 | — | — | WO | disclosed |
| WO-2024009191-A1 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2024-01-11 | — | — | WO | disclosed |