Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | KIF5B | P33176 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26984845 | 0.84 | MAPK1 (0.35) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL30746672 | 0.84 | MAPK1 (0.35) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL26985184 | 0.82 | CLK1 (0.34) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL30746457 | 0.82 | CLK1 (0.34) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL26984886 | 0.82 | KMT2A (0.34) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL30746469 | 0.82 | KMT2A (0.34) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL26985095 | 0.80 | RAF1 (0.42) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL30746420 | 0.80 | RAF1 (0.42) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL30746542 | 0.79 | HDAC3 (0.39) | EGFRKDRGAA | |
| SCHEMBL30746491 | 0.79 | SLC22A12 (0.36) | CLK1MAPK1RETEGFRKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |