Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 5/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP4X1 | Q8N118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31506282 | 1.00 | TRPM8 (0.45) | TRPM8MAPK14AAK1ELANEPPARG | |
| SCHEMBL395095 | 0.89 | MRGPRX4 (0.42) | AAK1PPARGPPARAMRGPRX4TSHR | |
| SCHEMBL30831623 | 0.88 | TRPM8 (0.49) | TRPM8MAPK14AAK1PPARGPPARA | |
| SCHEMBL30831587 | 0.88 | TAAR1 (0.45) | MRGPRX4TSHRMAPK1TDP1L3MBTL1 | |
| SCHEMBL23436 | 0.88 | TAAR1 (0.45) | MRGPRX4TSHRMAPK1TDP1L3MBTL1 | |
| SCHEMBL18833 | 0.88 | TAAR1 (0.45) | MRGPRX4TSHRMAPK1TDP1L3MBTL1 | |
| SCHEMBL18482288 | 0.80 | AAK1 (0.45) | AAK1PPARGPPARAMRGPRX4EPHX2 | |
| SCHEMBL26995244 | 0.79 | RAB9A (0.47) | MRGPRX4MAPK1L3MBTL1 | |
| SCHEMBL30831549 | 0.79 | RAB9A (0.47) | MRGPRX4MAPK1L3MBTL1 | |
| SCHEMBL5311248 | 0.78 | AAK1 (0.42) | AAK1PPARGEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024008941-A1 | NEW SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2024-01-11 | — | — | WO | disclosed |