Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 2/20 | 1.00 |
| ▸ | PKN2 | Q16513 | 2/20 | 1.00 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.77 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.77 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.77 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19994427 | 1.00 | PKN1 (1.00) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL19994531 | 0.87 | SIRT2 (0.79) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL19994496 | 0.83 | SIRT2 (0.72) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL2807193 | 0.83 | CHEK2 (0.73) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL6169071 | 0.80 | PKN1 (0.67) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL4259320 | 0.80 | PKN1 (0.77) | PKN1PKN2NPC1RAB9ACHEK2 | |
| SCHEMBL2357098 | 0.80 | CHEK2 (0.74) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL8248442 | 0.79 | PKN1 (0.65) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL17275543 | 0.79 | PKN1 (0.65) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL9261347 | 0.79 | ALDH1A1 (0.74) | PKN1PKN2SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515904-B1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2024-01-17 | — | — | EP | disclosed |