Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.72 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.72 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.72 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.71 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.66 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.65 |
| ▸ | MMP2 | P08253 | 3/20 | 0.64 |
| ▸ | MMP9 | P14780 | 3/20 | 0.64 |
| ▸ | MMP8 | P22894 | 3/20 | 0.64 |
| ▸ | MMP13 | P45452 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.62 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19995192 | 0.88 | NPBWR1 (0.69) | CHEK2NPBWR1MMP2MMP9MMP8 | |
| SCHEMBL27651947 | 0.87 | NPBWR1 (0.59) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL20982711 | 0.85 | SIRT2 (0.64) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL19994531 | 0.84 | SIRT2 (0.79) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL19994427 | 0.83 | PKN1 (1.00) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL27002575 | 0.83 | PKN1 (1.00) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL5217725 | 0.83 | CHEK2 (0.87) | CHEK2NPBWR1MMP2MMP9MMP8 | |
| SCHEMBL27002550 | 0.82 | CHEK2 (0.87) | PKN1PKN2CHEK2NPBWR1MMP2 | |
| SCHEMBL19994503 | 0.82 | CHEK2 (0.87) | PKN1PKN2CHEK2NPBWR1MMP2 | |
| SCHEMBL5219206 | 0.81 | NPBWR1 (0.77) | PKN1PKN2CHEK2NPBWR1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12509465-B2 | Benzoimidazole derivatives as anticancer agents | CENTRE LEON BERARD (FR) | 2025-12-30 | — | — | US | disclosed |
| EP-3515904-B1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2024-01-17 | — | — | EP | disclosed |
| CN-110234640-B | Benzimidazole derivatives as anticancer agents | 利昂贝拉尔中心 | 2023-04-07 | — | — | CN | disclosed |
| US-20220348587-A1 | Benzoimidazole Derivatives As Anticancer Agents | CENTRE LEON BERARD (FR) | 2022-11-03 | — | — | US | disclosed |
| US-11384081-B2 | Benzoimidazole derivatives as anticancer agents | CENTRE LEON BERARD (FR) | 2022-07-12 | — | — | US | disclosed |
| US-20210292328-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2021-09-23 | — | — | US | disclosed |
| EP-3515904-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | Centre Leon Berard (FR) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018054989-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509465-B2 | Benzoimidazole derivatives as anticancer agents | CCAR2, MAPKAP1, BCOR | SIRT2 1935/4885SIRT1 2148/4885SIRT3 1770/4885 |
| US-20210292328-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | TMBIM6, BAX, MAPK14 | SIRT2 1954/4885SIRT1 2241/4885SIRT3 1988/4885 |
| US-11384081-B2 | Benzoimidazole derivatives as anticancer agents | TMBIM6, BAX, MAPK14 | SIRT2 1954/4885SIRT1 2241/4885SIRT3 1988/4885 |
| US-20220348587-A1 | Benzoimidazole Derivatives As Anticancer Agents | TMBIM6, BAX, BCL2 | SIRT2 1990/4885SIRT1 2253/4885SIRT3 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.