SCHEMBL27005506

SCHEMBL27005506

COc1ccc(-c2sc(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)cc2-c2ccc(C#N)c(F)c2)cc1F

nearest known ligand 0.48

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 3/20 0.48
KDM1A O60341 12/20 0.43
CFTR P13569 1/20 0.40
RET P07949 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27005510 0.98 GPR119 (0.46) GPR119KDM1ACFTR
SCHEMBL27005524 0.92 KDM1A (0.43) GPR119KDM1ARET
SCHEMBL27005519 0.91 KDM1A (0.47) GPR119KDM1A
SCHEMBL27005539 0.89 KDM1A (0.51) KDM1A
SCHEMBL27005514 0.88 KDM1A (0.50) KDM1A
SCHEMBL27005472 0.88 KDM1A (0.50) KDM1A
SCHEMBL27005670 0.87 KDM1A (0.45) GPR119KDM1A
SCHEMBL27005503 0.87 KDM1A (0.44) GPR119KDM1ACFTR
SCHEMBL27004945 0.86 KDM1A (0.56) KDM1A
SCHEMBL27005025 0.85 KDM1A (0.50) KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4306520-A1 THIOPHENE COMPOUND AND APPLICATION THEREOF Medshine Discovery Inc. (CN) 2024-01-17 EP disclosed