Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067744 | 1.00 | ALDH1A1 (0.40) | ALDH1A1LMNAKMT2AMEN1PTGS1 | |
| SCHEMBL2700348 | 0.91 | GNRHR (0.35) | ALDH1A1LMNA | |
| SCHEMBL1066291 | 0.91 | GNRHR (0.35) | ALDH1A1LMNA | |
| SCHEMBL1064048 | 0.90 | PTGS2 (0.41) | ALDH1A1LMNAKMT2AMEN1PTGS1 | |
| SCHEMBL1064053 | 0.90 | PTGS2 (0.41) | ALDH1A1LMNAKMT2AMEN1PTGS1 | |
| SCHEMBL2702153 | 0.90 | ALDH1A1 (0.44) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL1066059 | 0.90 | ALDH1A1 (0.44) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL2703301 | 0.89 | ALDH1A1 (0.40) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL1069541 | 0.89 | ALDH1A1 (0.40) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL1066802 | 0.88 | ALDH1A1 (0.34) | ALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274297-B1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2012-05-09 | — | — | EP | disclosed |
| US-7741327-B2 | Pyrrolidinone glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | BERTHEL STEVEN JOSEPH | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | GCKR, GCK, PDK2 | ALDH1A1 1129/4885LMNA 3936/4885KMT2A 2072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.