Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27759126 | 0.80 | CHRM2 (0.36) | CHRM2CHRM5CHRM3CHRM4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28219697 | 0.77 | TSHR (0.34) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27792028 | 0.73 | TSHR (0.34) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1304769 | 0.72 | TSHR (0.35) | — | |
| Hydrochloric Acid SCHEMBL27759135 | 0.71 | CHRM2 (0.39) | CHRM2CHRM5CHRM3CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL28736100 | 0.70 | TSHR (0.32) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27919664 | 0.70 | BLM (0.38) | — | |
| Iodide SCHEMBL28038909 | 0.70 | TSHR (0.34) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL422092 | 0.68 | TSHR (0.36) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2701711 | 0.68 | PRKD3 (0.34) | CHRM2CHRM5CHRM3CHRM4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545876-B1 | LIQUID UNCROSSLINKED MICHAEL ADDITION OLIGOMERS PREPARED IN THE PRESENCE OF A CATALYST HAVING BOTH AN EPOXY MOIETY AND A QUATERNARY SALT | ASHLAND LICENSING & INTELLECTU (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-1545876-A4 | LIQUID UNCROSSLINKED MICHAEL ADDITION OLIGOMERS PREPARED IN THE PRESENCE OF A CATALYST HAVING BOTH AN EPOXY MOIETY AND A QUATERNARY SALT | ASHLAND LICENSING & INTELLECTU (US) | 2008-10-01 | — | — | EP | disclosed |
| CN-100377874-C | Liquid uncrosslinked michael addition oligomers prepared in the presence of a catalyst having both an epoxy moiety and a quaternary salt | ASHLAND INC (US) | 2008-04-02 | — | — | CN | disclosed |
| CN-1708401-A | Liquid uncrosslinked michael addition oligomers prepared in the presence of a catalyst having both an epoxy moiety and a quaternary salt | ASHLAND INC (US) | 2005-12-14 | — | — | CN | disclosed |
| EP-1545876-A2 | LIQUID UNCROSSLINKED MICHAEL ADDITION OLIGOMERS PREPARED IN THE PRESENCE OF A CATALYST HAVING BOTH AN EPOXY MOIETY AND A QUATERNARY SALT | ASHLAND INC. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004029118-A2 | LIQUID UNCROSSLINKED MICHAEL ADDITION OLIGOMERS PREPARED IN THE PRESENCE OF A CATALYST HAVING BOTH AN EPOXY MOIETY AND A QUATERNARY SALT | ASHLAND INC. (US) | 2004-04-08 | — | — | WO | disclosed |
| US-6706414-B1 | Liquid uncrosslinked Michael addition oligomers prepared in the presence of a catalyst having both an epoxy moiety and a quaternary salt | ASHLAND INC. | 2004-03-16 | — | — | US | disclosed |