Hydrochloric Acid

Hydrochloric Acid

SCHEMBL2701711

C=CC(=O)CC[N+](C)(C)CC1CO1.[Cl-]

nearest known ligand 0.34

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Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 4/20 0.33
CHRM1 known ✓ P11229 2/20 0.33
CHRM3 known ✓ P20309 3/20 0.32
PRKD3 O94806 2/20 0.34
PRKCG P05129 2/20 0.34
PRKCB P05771 2/20 0.34
PRKCA P17252 2/20 0.34
PRKCH P24723 2/20 0.34
PRKCI P41743 2/20 0.34
PRKCE Q02156 2/20 0.34
PRKCQ Q04759 2/20 0.34
PRKCZ Q05513 2/20 0.34
PRKCD Q05655 2/20 0.34
PRKD1 Q15139 2/20 0.34
BBOX1 O75936 1/20 0.33
CHRM5 P08912 4/20 0.33
TSHR P16473 2/20 0.33
MAPK1 P28482 1/20 0.33
CHRM4 P08173 2/20 0.32
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27759124 0.80 BBOX1 (0.38) PRKD3PRKCGPRKCBPRKCAPRKCH
Acrylamide SCHEMBL5605688 0.78 PRKD3 (0.38) PRKD3PRKCGPRKCBPRKCAPRKCH
Hydrochloric Acid SCHEMBL28219695 0.77 TSHR (0.40) PRKD3PRKCGPRKCBPRKCAPRKCH
Hydrochloric Acid SCHEMBL1304770 0.75 KMT2A (0.43) PRKD3PRKCGPRKCBPRKCAPRKCH
Hydrochloric Acid SCHEMBL28173697 0.75 PRKD3 (0.36) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL19164287 0.72 CHRM2 (0.48) PRKD3PRKCGPRKCBPRKCAPRKCH
Hydrochloric Acid SCHEMBL8881887 0.71 PRKD3 (0.47) PRKD3PRKCGPRKCBPRKCAPRKCH
Hydrochloric Acid SCHEMBL10903569 0.70 PRKD3 (0.46) PRKD3PRKCGPRKCBPRKCAPRKCH
Hydrochloric Acid SCHEMBL422093 0.70 ACHE (0.44) BBOX1CHRM2CHRM5CHRM1TSHR
Hydrochloric Acid SCHEMBL1415293 0.70 CHRM2 (0.50) PRKD3PRKCGPRKCBPRKCAPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1545876-B1 LIQUID UNCROSSLINKED MICHAEL ADDITION OLIGOMERS PREPARED IN THE PRESENCE OF A CATALYST HAVING BOTH AN EPOXY MOIETY AND A QUATERNARY SALT ASHLAND LICENSING & INTELLECTU (US) 2012-05-09 EP disclosed
EP-1545876-A4 LIQUID UNCROSSLINKED MICHAEL ADDITION OLIGOMERS PREPARED IN THE PRESENCE OF A CATALYST HAVING BOTH AN EPOXY MOIETY AND A QUATERNARY SALT ASHLAND LICENSING & INTELLECTU (US) 2008-10-01 EP disclosed
CN-100377874-C Liquid uncrosslinked michael addition oligomers prepared in the presence of a catalyst having both an epoxy moiety and a quaternary salt ASHLAND INC (US) 2008-04-02 CN disclosed
CN-1708401-A Liquid uncrosslinked michael addition oligomers prepared in the presence of a catalyst having both an epoxy moiety and a quaternary salt ASHLAND INC (US) 2005-12-14 CN disclosed
EP-1545876-A2 LIQUID UNCROSSLINKED MICHAEL ADDITION OLIGOMERS PREPARED IN THE PRESENCE OF A CATALYST HAVING BOTH AN EPOXY MOIETY AND A QUATERNARY SALT ASHLAND INC. (US) 2005-06-29 EP disclosed
WO-2004029118-A2 LIQUID UNCROSSLINKED MICHAEL ADDITION OLIGOMERS PREPARED IN THE PRESENCE OF A CATALYST HAVING BOTH AN EPOXY MOIETY AND A QUATERNARY SALT ASHLAND INC. (US) 2004-04-08 WO disclosed
US-6706414-B1 Liquid uncrosslinked Michael addition oligomers prepared in the presence of a catalyst having both an epoxy moiety and a quaternary salt ASHLAND INC. 2004-03-16 US disclosed