SCHEMBL27017367

SCHEMBL27017367

COC(=O)[C@@H]1C[C@H](Oc2ccccc2[N+](=O)[O-])CN1C(=O)OC(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 16/20 0.44
BCL2 P10415 5/20 0.42
BCL2L1 Q07817 3/20 0.42
P2RX3 P56373 1/20 0.41
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41
GPR119 Q8TDV5 1/20 0.40
UCHL1 P09936 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7971998 0.90 MCL1 (0.45) MCL1BCL2BCL2L1GPR119UCHL1
SCHEMBL6847596 0.90 MCL1 (0.45) MCL1BCL2BCL2L1GPR119UCHL1
SCHEMBL7971995 0.90 MCL1 (0.45) MCL1BCL2BCL2L1GPR119UCHL1
SCHEMBL6847593 0.90 MCL1 (0.45) MCL1BCL2BCL2L1GPR119UCHL1
SCHEMBL2408809 0.89 P2RX3 (0.41) MCL1BCL2BCL2L1P2RX3NR1H2
SCHEMBL2408811 0.89 P2RX3 (0.41) MCL1BCL2BCL2L1P2RX3NR1H2
SCHEMBL30170377 0.87 P2RX3 (0.41) MCL1BCL2BCL2L1P2RX3NR1H2
SCHEMBL27017548 0.87 P2RX3 (0.41) MCL1BCL2BCL2L1P2RX3NR1H2
SCHEMBL24739556 0.83 NR1H2 (0.43) MCL1P2RX3NR1H2NR1H3GPR119
SCHEMBL13481242 0.83 NR1H2 (0.43) MCL1P2RX3NR1H2NR1H3GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250243187-A1 ANTI-VIRAL COMPOUNDS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-07-31 US disclosed
EP-4551569-A1 ANTI-VIRAL COMPOUNDS Aligos Therapeutics, Inc. (US) 2025-05-14 EP disclosed
EP-4366831-A1 ANTI-VIRAL COMPOUNDS Aligos Therapeutics, Inc. (US) 2024-05-15 EP disclosed
US-20240109871-A1 ANTI-VIRAL COMPOUNDS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2024-04-04 US disclosed
US-20240018126-A1 ANTI-VIRAL COMPOUNDS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2024-01-18 US disclosed
US-20240018126-A1 ANTI-VIRAL COMPOUNDS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2024-01-18 US disclosed
US-11851422-B2 Anti-viral compounds ALIGOS THERAPEUTICS, INC. 2023-12-26 US disclosed
US-20230093249-A1 ANTI-VIRAL COMPOUNDS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-03-23 US disclosed
WO-2023283256-A1 ANTI-VIRAL COMPOUNDS ALIGOS THERAPEUTICS, INC. (US) 2023-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250243187-A1 ANTI-VIRAL COMPOUNDS EIF2AK2, ZC3HAV1, HAVCR2 MCL1 1723/4885BCL2 3829/4885BCL2L1 3193/4885
US-20230093249-A1 ANTI-VIRAL COMPOUNDS EIF2AK2, ZC3HAV1, HAVCR2 MCL1 1723/4885BCL2 3829/4885BCL2L1 3193/4885
US-11851422-B2 Anti-viral compounds EIF2AK2, ZC3HAV1, HAVCR2 MCL1 1723/4885BCL2 3829/4885BCL2L1 3193/4885
US-20240018126-A1 ANTI-VIRAL COMPOUNDS EIF2AK2, ZC3HAV1, HAVCR2 MCL1 1723/4885BCL2 3829/4885BCL2L1 3193/4885
US-20240109871-A1 ANTI-VIRAL COMPOUNDS EIF2AK2, ZC3HAV1, HAVCR2 MCL1 1723/4885BCL2 3829/4885BCL2L1 3193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.