Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | SCN2B | O60939 | 1/20 | 0.39 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.35 |
| ▸ | CKS1B | P61024 | 2/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27021659 | 0.82 | L3MBTL1 (0.41) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL26898660 | 0.81 | ALDH1A1 (0.40) | CHRNA7BACE1TDP1ALDH1A1GAA | |
| SCHEMBL18798786 | 0.79 | MRGPRX1 (0.46) | SCN9AALDH1A1MRGPRX1LMNASCN5A | |
| SCHEMBL26898635 | 0.78 | BACE1 (0.38) | BACE1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL26856720 | 0.78 | KDM4E (0.50) | ALDH1A1KDM4EGAA | |
| SCHEMBL26856985 | 0.77 | TLR7 (0.39) | BACE1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL26898659 | 0.77 | SCN9A (0.40) | SCN9AALDH1A1KDM4EGAALMNA | |
| SCHEMBL26856992 | 0.77 | GAA (0.40) | ALDH1A1KDM4EGAA | |
| SCHEMBL26898604 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL26874929 | 0.75 | CTSA (0.37) | BACE1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2024-01-18 | — | — | US | disclosed |
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2024-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | SCN9A 2496/4885SCN2B 1761/4885SCN1B 1229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.