Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.47 |
| ▸ | JAK2 | O60674 | 11/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30756767 | 0.94 | JAK1 (0.46) | JAK1JAK2KCNH2 | |
| SCHEMBL27129604 | 0.94 | JAK1 (0.46) | JAK1JAK2KCNH2 | |
| SCHEMBL26987692 | 0.94 | JAK1 (0.46) | JAK1JAK2KCNH2 | |
| SCHEMBL26993833 | 0.90 | JAK1 (0.47) | JAK1JAK2KCNH2 | |
| SCHEMBL30756769 | 0.90 | JAK1 (0.47) | JAK1JAK2KCNH2 | |
| SCHEMBL30757058 | 0.89 | JUN (0.43) | JAK1JAK2KCNH2 | |
| SCHEMBL26989308 | 0.89 | JUN (0.43) | JAK1JAK2KCNH2 | |
| SCHEMBL26987262 | 0.89 | JUN (0.43) | JAK1JAK2KCNH2 | |
| SCHEMBL30757243 | 0.88 | JAK1 (0.54) | JAK1JAK2KCNH2 | |
| SCHEMBL27030858 | 0.88 | JAK1 (0.45) | JAK1JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | claimed |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EIF2AK4, GCN1, GCGR | JAK1 4139/4885JAK2 4317/4885KCNH2 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.