Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | DGKA | P23743 | 1/20 | 0.36 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21831278 | 0.85 | MAPK14 (0.48) | DPP8MAPK14SLC6A9KDM4ECYP1A2 | |
| SCHEMBL21831860 | 0.85 | MAPK14 (0.48) | DPP8MAPK14SLC6A9KDM4ECYP1A2 | |
| SCHEMBL21831485 | 0.85 | MAPK14 (0.48) | DPP8MAPK14SLC6A9KDM4ECYP1A2 | |
| SCHEMBL25328436 | 0.85 | MAPK14 (0.48) | DPP8MAPK14SLC6A9KDM4ECYP1A2 | |
| SCHEMBL21831052 | 0.85 | DPP8 (0.39) | DPP8MAPK14SLC6A9MEN1KMT2A | |
| SCHEMBL21831875 | 0.85 | DPP8 (0.39) | DPP8MAPK14SLC6A9MEN1KMT2A | |
| SCHEMBL27048125 | 0.83 | PDK1 (0.43) | DPP8SLC6A3 | |
| SCHEMBL26926141 | 0.80 | CACNA1B (0.38) | DPP8MEN1KMT2ACYP3A4DGKA | |
| SCHEMBL21831325 | 0.78 | DGKA (0.43) | DPP8CYP2C9CYP2C19OPRD1DGKA | |
| SCHEMBL26925710 | 0.78 | DPP8 (0.39) | DPP8MAPK14SLC6A9KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025900-A1 | TETRACYCLIC COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025900-A1 | TETRACYCLIC COMPOUNDS AS DGK INHIBITORS | DGKA, DGKG, DGKI | DPP8 1369/4885MAPK14 518/4885SLC6A9 3577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.