Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GPR17 | Q13304 | 5/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5671480 | 0.64 | KDM4E (0.35) | — | |
| SCHEMBL17550623 | 0.60 | MEN1 (0.35) | — | |
| SCHEMBL16258009 | 0.59 | — | — | |
| SCHEMBL12864086 | 0.58 | JAK2 (0.39) | JAK2THRBGPR17 | |
| SCHEMBL1242676 | 0.58 | DAO (0.42) | GPR17 | |
| SCHEMBL1959035 | 0.58 | — | — | |
| SCHEMBL11130450 | 0.57 | JAK2 (0.57) | JAK2THRB | |
| Trifluoroacetic Acid SCHEMBL3855786 | 0.57 | CES1 (0.31) | — | |
| SCHEMBL16323633 | 0.57 | MEN1 (0.36) | — | |
| SCHEMBL28845799 | 0.57 | JAK2 (0.52) | JAK2THRBGPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118146228-A | Deuterated spiro compound crystal form and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2024017270-A1 | SPIRO COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳信立泰药业股份有限公司 | 2024-01-25 | — | — | WO | disclosed |
| CN-116621918-B | Spiro compound and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116621918-A | Spiro compound and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2023-08-22 | — | — | CN | disclosed |