Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.34 |
| ▸ | YAP1 | P46937 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ADAMTS7 | Q9UKP4 | 8/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30683347 | 0.90 | TEAD1 (0.34) | TEAD1YAP1EGFRFGFR1KDR | |
| SCHEMBL27035701 | 0.78 | TEAD1 (0.58) | TEAD1YAP1EGFRFGFR1KDR | |
| SCHEMBL27035565 | 0.74 | EGFR (0.37) | TEAD1YAP1EGFRFGFR1KDR | |
| SCHEMBL27035575 | 0.71 | KDM2B (0.38) | TEAD1YAP1EGFRFGFR1KDR | |
| SCHEMBL543065 | 0.68 | MEN1 (0.48) | MEN1KMT2ALMNAMMP2ADAMTS4 | |
| SCHEMBL30683324 | 0.66 | TEAD1 (0.35) | TEAD1YAP1EGFRFGFR1KDR | |
| SCHEMBL27035652 | 0.64 | LMNA (0.40) | MEN1KMT2ALMNA | |
| SCHEMBL20135251 | 0.63 | LMNA (0.46) | MEN1KMT2ALMNA | |
| SCHEMBL377317 | 0.62 | LMNA (0.47) | LMNAAR | |
| SCHEMBL29949282 | 0.62 | LMNA (0.47) | LMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020350-A1 | TEAD INHIBITORS AND METHODS OF USE | SPOROS BIODISCOVERY, INC. (US) | 2024-01-25 | — | — | WO | disclosed |