Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.58 |
| ▸ | YAP1 | P46937 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.34 |
| ▸ | ADAMTS7 | Q9UKP4 | 4/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 2/20 | 0.32 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27035555 | 0.83 | TEAD1 (0.58) | TEAD1YAP1TSHRL3MBTL1EGFR | |
| SCHEMBL27035557 | 0.83 | TEAD1 (0.55) | TEAD1YAP1TSHRL3MBTL1EGFR | |
| SCHEMBL27035578 | 0.81 | TEAD1 (0.53) | TEAD1YAP1TSHRL3MBTL1EGFR | |
| SCHEMBL25877139 | 0.78 | TEAD1 (0.66) | TEAD1YAP1TSHRL3MBTL1EGFR | |
| SCHEMBL27035560 | 0.78 | TEAD1 (0.34) | TEAD1YAP1TSHRL3MBTL1EGFR | |
| SCHEMBL25877124 | 0.77 | TEAD1 (0.71) | TEAD1YAP1TSHRL3MBTL1EGFR | |
| SCHEMBL30683347 | 0.77 | TEAD1 (0.34) | TEAD1YAP1EGFRFGFR1KDR | |
| SCHEMBL30503081 | 0.76 | TEAD1 (0.67) | TEAD1YAP1TSHRL3MBTL1EGFR | |
| SCHEMBL25877140 | 0.76 | TEAD1 (0.67) | TEAD1YAP1TSHRL3MBTL1EGFR | |
| SCHEMBL25314394 | 0.76 | TEAD1 (0.67) | TEAD1YAP1TSHRL3MBTL1TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558485-A1 | TEAD INHIBITORS AND METHODS OF USE | Sporos Biodiscovery, Inc. (US) | 2025-05-28 | — | — | EP | disclosed |
| WO-2024020350-A1 | TEAD INHIBITORS AND METHODS OF USE | SPOROS BIODISCOVERY, INC. (US) | 2024-01-25 | — | — | WO | disclosed |