Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 17/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 11/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27080875 | 0.94 | CD274 (0.44) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL29983940 | 0.94 | CD274 (0.44) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL27036623 | 0.87 | CCR4 (0.39) | CCR4CD274PDCD1LG2PDCD1 | |
| SCHEMBL23725268 | 0.81 | CD274 (0.42) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL29143920 | 0.80 | CD274 (0.45) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL23725091 | 0.79 | CD274 (0.45) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL29984282 | 0.76 | PDCD1LG2 (0.40) | CCR4CD274PDCD1LG2 | |
| SCHEMBL27036467 | 0.76 | PDCD1LG2 (0.40) | CCR4CD274PDCD1LG2 | |
| SCHEMBL29144128 | 0.76 | SQOR (0.41) | CD274PDCD1ALDH1A1 | |
| SCHEMBL23726178 | 0.74 | CD274 (0.36) | CD274PDCD1LG2PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024069448-A1 | SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-04-04 | — | — | WO | disclosed |
| WO-2024018403-A1 | SUBSTITUTED IMIDAZOAMIDE COMPOUNDS, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-01-25 | — | — | WO | disclosed |