Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 3/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27041543 | 1.00 | TLR2 (0.49) | TLR2MDM2CTSLCTSBPTPN1 | |
| SCHEMBL12476100 | 0.91 | TLR2 (0.55) | TLR2MDM2PTPN1MDM4TP53 | |
| SCHEMBL12476097 | 0.91 | TLR2 (0.55) | TLR2MDM2PTPN1MDM4TP53 | |
| SCHEMBL28615852 | 0.91 | TLR2 (0.55) | TLR2MDM2PTPN1MDM4TP53 | |
| SCHEMBL18683448 | 0.91 | TLR2 (0.55) | TLR2MDM2PTPN1MDM4TP53 | |
| SCHEMBL30143778 | 0.91 | MDM4 (0.51) | MDM2CTSLCTSBPTPN1MDM4 | |
| SCHEMBL30759394 | 0.90 | CTSL (0.46) | TLR2MDM2CTSLCTSBPTPN1 | |
| SCHEMBL29413323 | 0.89 | MDM4 (0.49) | CTSLCTSBPTPN1MDM4TP53 | |
| SCHEMBL15342315 | 0.89 | MDM4 (0.49) | CTSLCTSBPTPN1MDM4TP53 | |
| SCHEMBL30759470 | 0.87 | TLR2 (0.47) | TLR2MDM2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020159-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2024-01-25 | — | — | WO | disclosed |