Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184233 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KDM4EALOX15MAPTKMT2A | |
| SCHEMBL10004132 | 0.88 | MAOB (0.48) | ALDH1A1KDM4EALOX15MAPTKMT2A | |
| SCHEMBL20472390 | 0.85 | KDM4E (0.62) | ALDH1A1KDM4EALOX15MAPTKMT2A | |
| SCHEMBL29786432 | 0.85 | KDM4E (0.62) | ALDH1A1KDM4EALOX15MAPTKMT2A | |
| SCHEMBL4738082 | 0.85 | CYP4F2 (0.50) | ALDH1A1KDM4EALOX15MAPTKMT2A | |
| SCHEMBL31128387 | 0.84 | KDM4E (0.56) | ALDH1A1KDM4EALOX15MAPTKMT2A | |
| SCHEMBL4737125 | 0.84 | KDM4E (0.56) | ALDH1A1KDM4EALOX15MAPTTDP1 | |
| SCHEMBL2929292 | 0.83 | KDM4E (0.55) | ALDH1A1KDM4EALOX15MAPTKMT2A | |
| SCHEMBL31184306 | 0.82 | MAOB (0.44) | ALDH1A1KDM4EALOX15MAPTKMT2A | |
| SCHEMBL31483916 | 0.81 | KDM4E (0.57) | ALDH1A1KDM4EALOX15MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12552790-B2 | Positive modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2026-02-17 | — | — | US | disclosed |
| US-20260035366-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | UNIV VANDERBILT (US) | 2026-02-05 | — | — | US | disclosed |
| US-12448380-B2 | Positive modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2025-10-21 | — | — | US | disclosed |
| US-12344608-B2 | Positive modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2025-07-01 | — | — | US | disclosed |
| US-20250136600-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2025-05-01 | — | — | US | disclosed |
| US-20250122200-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2025-04-17 | — | — | US | disclosed |
| US-20250122199-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2025-04-17 | — | — | US | disclosed |
| US-20250122201-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2025-04-17 | — | — | US | disclosed |
| US-20250122198-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2025-04-17 | — | — | US | disclosed |
| US-20250011320-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2025-01-09 | — | — | US | disclosed |
| EP-2450350-A1 | 3-Pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as HDL-cholesterol raising agents | F. Hoffmann-La Roche AG (CH) | 2012-05-09 | — | — | EP | disclosed |
| US-20100267745-A1 | 3-Pyridinecarboxamide Derivatives as HDL-Cholesterol Raising Agents | ANDJELKOVIC MIRJANA | 2010-10-21 | — | — | US | disclosed |
| US-7812028-B2 | 3-pyridinecarboxamide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2010-10-12 | — | — | US | disclosed |
| CN-101522626-A | 3-pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as HDL-cholesterol raising agents | HOFFMANN LA ROCHE (CH) | 2009-09-02 | — | — | CN | disclosed |
| EP-2074096-A1 | 3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| US-20090143409-A1 | 3-PYRIDINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | ANDJELKOVIC MIRJANA | 2009-06-04 | — | — | US | disclosed |
| US-20080200448-A1 | reversible and selective purinergic receptor P2Y12 antagonists; anticoagulants; cardiovascular disorders; e.g. ethyl 2-acetoxy-6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyanonicotinate | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | US | disclosed |
| WO-2008085119-A1 | NEW PYRIDINE ANALOGUES VIII 518 | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |
| US-20080085906-A1 | 3-Pyridinecarboxamide derivatives as HDL-cholesterol raising agents | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-10 | — | — | US | disclosed |
| WO-2008040651-A1 | 3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122200-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM1, CHRM3 | ALDH1A1 2993/4885KDM4E 753/4885ALOX15 4041/4885 |
| US-12552790-B2 | Positive modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM1, CHRM5 | ALDH1A1 2392/4885KDM4E 437/4885ALOX15 4512/4885 |
| US-20080085906-A1 | 3-Pyridinecarboxamide derivatives as HDL-cholesterol raising agents | CETP, APOB, LDLR | ALDH1A1 1799/4885KDM4E 1694/4885ALOX15 3874/4885 |
| US-20250011320-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM1, CHRM3 | ALDH1A1 2993/4885KDM4E 753/4885ALOX15 4041/4885 |
| US-20250136600-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM1, CHRM3 | ALDH1A1 2993/4885KDM4E 753/4885ALOX15 4041/4885 |
| US-20250122201-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM1, CHRM3 | ALDH1A1 2993/4885KDM4E 753/4885ALOX15 4041/4885 |
| US-20090143409-A1 | 3-PYRIDINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | CETP, APOB, LDLR | ALDH1A1 1799/4885KDM4E 1694/4885ALOX15 3874/4885 |
| US-20080200448-A1 | reversible and selective purinergic receptor P2Y12 antagonists; anticoagulants; cardiovascular disorders; e.g. ethyl 2-acetoxy-6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyanonicotinate | P2RY12, P2RY13, P2RY11 | ALDH1A1 2394/4885KDM4E 2864/4885ALOX15 976/4885 |
| US-12344608-B2 | Positive modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM1, CHRM3 | ALDH1A1 2993/4885KDM4E 753/4885ALOX15 4041/4885 |
| US-20250122198-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM1, CHRM3 | ALDH1A1 2993/4885KDM4E 753/4885ALOX15 4041/4885 |
| US-20250122199-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM1, CHRM3 | ALDH1A1 2993/4885KDM4E 753/4885ALOX15 4041/4885 |
| US-20100267745-A1 | 3-Pyridinecarboxamide Derivatives as HDL-Cholesterol Raising Agents | CETP, APOB, LDLR | ALDH1A1 1799/4885KDM4E 1694/4885ALOX15 3874/4885 |
| US-20260035366-A1 | POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM3, CHRM5 | ALDH1A1 3334/4885KDM4E 775/4885ALOX15 3943/4885 |
| US-12448380-B2 | Positive modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM1, CHRM3 | ALDH1A1 2993/4885KDM4E 753/4885ALOX15 4041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.