Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 2/20 | 0.38 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2704931 | 0.88 | PER2 (0.33) | PER2CRY2 | |
| SCHEMBL9409718 | 0.77 | OPRM1 (0.31) | MAOBCYP2D6 | |
| SCHEMBL9409723 | 0.77 | CHRM2 (0.57) | CHRM2CHRM5CYP2D6CHRM1CHRM3 | |
| SCHEMBL19383610 | 0.75 | PER2 (0.42) | PER2CRY2BRD4BRD2 | |
| SCHEMBL11934366 | 0.75 | PER2 (0.42) | PER2CRY2BRD4BRD2ALDH1A1 | |
| SCHEMBL13208691 | 0.74 | PER2 (0.41) | PER2CRY2BRD4BRD2ALDH1A1 | |
| SCHEMBL1445993 | 0.74 | PER2 (0.41) | PER2CRY2BRD4BRD2 | |
| SCHEMBL1446202 | 0.74 | PER2 (0.41) | PER2CRY2BRD4BRD2 | |
| SCHEMBL1446055 | 0.72 | PER2 (0.40) | PER2CRY2BRD4BRD2TSHR | |
| SCHEMBL1446205 | 0.72 | PER2 (0.43) | PER2CRY2BRD4BRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492536-B1 | 4-(N-PHENYLAMINO)-QUINAZOLINES / QUINOLINES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2012-05-09 | — | — | EP | claimed |