Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SELP | P16109 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394637 | 0.85 | GPR119 (0.57) | GPR119KCNH2CHEK1IKBKBAURKA | |
| SCHEMBL2391502 | 0.85 | GPR119 (0.57) | GPR119KCNH2CHEK1IKBKBAURKA | |
| SCHEMBL2394461 | 0.80 | GPR119 (0.47) | GPR119KCNH2CHEK1IKBKBAURKA | |
| SCHEMBL2393744 | 0.80 | GPR119 (0.47) | GPR119KCNH2CHEK1IKBKBAURKA | |
| SCHEMBL2392822 | 0.75 | GPR119 (0.48) | GPR119KCNH2CHEK1IKBKBAURKA | |
| SCHEMBL2396672 | 0.75 | GPR119 (0.48) | GPR119KCNH2CHEK1IKBKBAURKA | |
| SCHEMBL13534631 | 0.72 | GPR119 (0.62) | GPR119KCNH2HRH3BMPR1BBMPR1A | |
| SCHEMBL2219251 | 0.72 | GPR119 (0.42) | GPR119KCNH2TYK2 | |
| SCHEMBL2215240 | 0.72 | GPR119 (0.42) | GPR119KCNH2TYK2 | |
| SCHEMBL2216070 | 0.72 | GPR119 (0.42) | GPR119KCNH2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321308-B9 | PIPERIDINE GPCR AGONISTS | PROSIDION LTD (GB) | 2012-08-08 | — | — | EP | claimed |
| EP-2321308-B1 | PIPERIDINE GPCR AGONISTS | PROSIDION LTD (GB) | 2012-05-09 | — | — | EP | claimed |