Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 13/20 | 0.38 |
| ▸ | CDK2 | P24941 | 13/20 | 0.38 |
| ▸ | CCND1 | P24385 | 10/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768102 | 0.83 | CCNE1 (0.55) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL27035042 | 0.83 | CCNE1 (0.55) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL23001261 | 0.77 | CDK2 (0.46) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL23001264 | 0.72 | ULK1 (0.49) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL22997835 | 0.72 | ACHE (0.42) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL15507839 | 0.72 | HASPIN (0.38) | — | |
| SCHEMBL23340858 | 0.71 | CDK2 (0.44) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL27063563 | 0.70 | EGFR (0.40) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL30726194 | 0.70 | CCNE1 (0.57) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL27033634 | 0.70 | CCNE1 (0.57) | CCNE1CDK2CCND1CDK6CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020419-A1 | AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE | IAMBIC THERAPEUTICS, INC. (US) | 2024-01-25 | — | — | WO | disclosed |