Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29682150 | 0.81 | DYRK1A (0.57) | RAB9ASMN1; SMN2NPC1DYRK1ACYP1A2 | |
| SCHEMBL25336208 | 0.81 | DYRK1A (0.57) | RAB9ASMN1; SMN2NPC1DYRK1ACYP1A2 | |
| SCHEMBL23921280 | 0.79 | LDHA (0.37) | LDHASHMT2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29006879 | 0.79 | CCNA2 (0.36) | RAB9ASMN1; SMN2NPC1MAPTCCNA2 | |
| SCHEMBL6067813 | 0.75 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1ALDH1A1HTT | |
| SCHEMBL658937 | 0.75 | APP (0.40) | LDHASHMT2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL25338656 | 0.75 | GAA (0.44) | RAB9ASMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL29682160 | 0.75 | GAA (0.44) | RAB9ASMN1; SMN2NPC1CYP1A2CYP3A4 | |
| SCHEMBL25338411 | 0.74 | NPC1 (0.56) | RAB9ASMN1; SMN2NPC1DYRK1AALDH1A1 | |
| SCHEMBL29682179 | 0.74 | NPC1 (0.56) | RAB9ASMN1; SMN2NPC1DYRK1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025893-A1 | PYRIMIDINE-AND NITROGEN-CONTAINING BICYCLIC COMPOUND | ASAHI KASEI PHARMA CORPORATION (JP) | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025893-A1 | PYRIMIDINE-AND NITROGEN-CONTAINING BICYCLIC COMPOUND | IRAK4, IRAK1, IRAK2 | LDHA 3420/4885SHMT2 1926/4885RAB9A 4106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.