SCHEMBL2707396

SCHEMBL2707396

O=C(Cl)c1nnn[nH]1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1238342 0.77
Fluoride SCHEMBL30940539 0.75
SCHEMBL6767923 0.75 LMNA (0.32)
SCHEMBL361611 0.75
SCHEMBL6316087 0.75 LMNA (0.32)
SCHEMBL968348 0.75
Hydrochloric Acid SCHEMBL9135847 0.73
Ammonia Solution, Strong SCHEMBL11220454 0.73
SCHEMBL10854768 0.73
Potassium Ion SCHEMBL15558850 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104306974-B The method of the ephrosis for the treatment of contrast agent induction 诺华股份有限公司 2017-06-13 CN disclosed
EP-2640375-B1 METHOD OF TREATING CONTRAST-INDUCED NEPHROPATHY NOVARTIS AG (CH) 2016-05-18 EP disclosed
EP-2435402-A2 SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS Novartis AG (CH) 2012-04-04 EP disclosed
WO-2010136474-A2 SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS NOVARTIS AG (CH) 2010-12-02 WO disclosed
US-6809101-B2 RNA POLYMERASES INHIBITORS; SUCH AS 5-(1-HYDROXY-1-(5-METHYL-OXAZOL-2-YL))METHYLENE-2-THIOXOTHIAZOLIDIN-4-ONE SHIONOGI & CO., LTD. (JP) 2004-10-26 US disclosed
US-6790978-B2 4-HYDROXY-3-ARYLSULFONYL, 3-AMINOSULFONYL OR 3-AMINOCARBONYL-PHENOXYANILINOCARBONYL-OPTIONAL ALKYLENE-CARBOXYLIC ACID OR CARBONYL-5-TETRAZOLES NOVARTIS AG (CH) 2004-09-14 US disclosed
US-20030203948-A1 Compounds having anti-hepatitics c virus effect Z-KAT, INC. 2003-10-30 US disclosed
US-20020045751-A1 Thyromimetic organic compounds NOVARTIS AG (CH) 2002-04-18 US disclosed
EP-0685478-B1 QUINOLINE DERIVATIVES UBE INDUSTRIES (JP) 2001-10-24 EP disclosed
CN-1046279-C Quinoline derivative UBE INDUSTRIES (JP) 1999-11-10 CN disclosed
US-4129735-A MULTISTAGE FROM AN OXAMIC ACID ESTER AND PHOSPHORUS PENTACHLORIDE AMERICAN HOME PRODUCTS CORPORATION (US) 1978-12-12 US disclosed
US-4123432-A ANTIALLERGENS AMERICAN HOME PRODUCTS CORPORATION (US) 1978-10-31 US disclosed
US-4116960-A ANTI-ALLERGIC AMERICAN HOME PRODUCTS CORPORATION (US) 1978-09-26 US disclosed
US-4112101-A N-(Pyridyl)-1H-(or 2H) tetrazole-5-carboxamide derivatives for the prevention of immediate type hypersensitivity reactions AMERICAN HOME PRODUCTS CORPORATION (US) 1978-09-05 US disclosed
US-4112106-A N-(2-thiazolyl)-tetrazole-5-carboxamide derivatives for the prevention of immediate type hypersensitivity reactions AMERICAN HOME PRODUCTS CORPORATION (US) 1978-09-05 US disclosed
US-4112094-A ANTIALLERGENS AMERICAN HOME PRODUCTS CORPORATION (US) 1978-09-05 US disclosed
US-4110453-A N-(2-PYRIMIDINYL)1H-(OR 2H)TETRAZOLE-5-CARBOXAMIDE DERIVATIVES FOR THE PREVENTION OF IMMEDIATE TYPE HYPERSENSITIVITY REACTIONS AMERICAN HOME PRODUCTS CORPORATION (US) 1978-08-29 US disclosed
US-4057632-A ANTIBODY-ANTIGEN INHIBITORS AMERICAN HOME PRODUCTS CORPORATION (US) 1977-11-08 US disclosed
US-4044144-A ANTIALLERGY AMERICAN HOME PRODUCTS CORPORATION (US) 1977-08-23 US disclosed
US-4013647-A ANTIALLERGENS AMERICAN HOME PRODUCTS CORPORATION (US) 1977-03-22 US disclosed