Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 7/20 | 0.51 |
| ▸ | MRGPRX1 | Q96LB2 | 6/20 | 0.35 |
| ▸ | TSPO | P30536 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1865942 | 1.00 | TLR4 (0.51) | TLR4MRGPRX1TSPOHRH1KCNH2 | |
| SCHEMBL1862065 | 1.00 | TLR4 (0.51) | TLR4MRGPRX1TSPOHRH1KCNH2 | |
| SCHEMBL1863192 | 1.00 | TLR4 (0.51) | TLR4MRGPRX1TSPOHRH1KCNH2 | |
| SCHEMBL1870373 | 0.92 | TLR4 (0.53) | TLR4MRGPRX1TSPOHRH1 | |
| SCHEMBL1868646 | 0.92 | TLR4 (0.53) | TLR4MRGPRX1TSPOHRH1MAPT | |
| SCHEMBL12634813 | 0.92 | TLR4 (0.53) | TLR4MRGPRX1TSPOHRH1MAPT | |
| SCHEMBL1865197 | 0.92 | TLR4 (0.53) | TLR4MRGPRX1TSPOHRH1 | |
| SCHEMBL1863515 | 0.92 | TLR4 (0.53) | TLR4MRGPRX1TSPOHRH1 | |
| SCHEMBL1866486 | 0.90 | TLR4 (0.65) | TLR4MRGPRX1TSPOHRH1NPSR1 | |
| SCHEMBL1862850 | 0.90 | TLR4 (0.65) | TLR4MRGPRX1TSPOHRH1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073689-A9 | Crystals of Substituted Cycloalkene Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-03-13 | — | — | US | claimed |
| EP-2620434-A1 | CRYSTALS OF SUBSTITUTED CYCLOALKENE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-31 | — | — | EP | claimed |
| US-20130178521-A1 | Crystals of Substituted Cycloalkene Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-11 | — | — | US | claimed |
| US-8933117-B2 | Crystals of substituted cycloalkene derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-13 | — | — | US | disclosed |
| US-8933117-B2 | Crystals of substituted cycloalkene derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-13 | — | — | US | disclosed |
| US-20140073689-A9 | Crystals of Substituted Cycloalkene Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-03-13 | — | — | US | disclosed |
| EP-2620434-A1 | CRYSTALS OF SUBSTITUTED CYCLOALKENE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-31 | — | — | EP | disclosed |
| EP-2620434-A1 | CRYSTALS OF SUBSTITUTED CYCLOALKENE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-31 | — | — | EP | disclosed |
| EP-2620434-A1 | CRYSTALS OF SUBSTITUTED CYCLOALKENE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-31 | — | — | EP | disclosed |
| US-20130178521-A1 | Crystals of Substituted Cycloalkene Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-11 | — | — | US | disclosed |
| WO-2012039447-A1 | CRYSTALS OF SUBSTITUTED CYCLOALKENE DERIVATIVES | 第一三共株式会社 (JP) | 2012-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178521-A1 | Crystals of Substituted Cycloalkene Derivatives | BAD, PYCARD, CASP8 | TLR4 8/4885MRGPRX1 899/4885TSPO 2420/4885 |
| US-20140073689-A9 | Crystals of Substituted Cycloalkene Derivatives | BAD, PYCARD, CASP8 | TLR4 8/4885MRGPRX1 899/4885TSPO 2420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.