Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29705723 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KMT2ARXRARXRBALOX5 | |
| SCHEMBL28941554 | 0.87 | ALDH1A1 (0.47) | ALDH1A1KMT2AALOX5LMNATSHR | |
| SCHEMBL1626965 | 0.86 | ICMT (0.48) | ALDH1A1KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL23164287 | 0.83 | KMT2A (0.47) | ALDH1A1KMT2AALOX5LMNATSHR | |
| SCHEMBL29705586 | 0.83 | KMT2A (0.47) | ALDH1A1KMT2AALOX5LMNATSHR | |
| SCHEMBL23164169 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KMT2ARXRARXRBLMNA | |
| SCHEMBL23164167 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KMT2ARXRARXRBLMNA | |
| SCHEMBL29705585 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KMT2ARXRARXRBLMNA | |
| SCHEMBL9911073 | 0.79 | HDAC4 (0.52) | ALDH1A1KMT2ALMNATSHRCYP2C19 | |
| SCHEMBL7807445 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4038052-B1 | PROSTAGLANDIN E2 (PGE2) EP4 RECEPTOR ANTAGONISTS | DOMAIN THERAPEUTICS (FR) | 2024-02-07 | — | — | EP | disclosed |
| CN-114555573-A | Prostaglandin E2(PGE2)EP4Receptor antagonists | 多曼治疗学公司 | 2022-05-27 | — | — | CN | disclosed |