Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 12/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18497935 | 0.81 | KDM4E (0.31) | ALDH1A1 | |
| SCHEMBL26812225 | 0.81 | SMN1; SMN2 (0.44) | KDM1ASMN1; SMN2EPHX1EPHX2CD274 | |
| SCHEMBL27172421 | 0.77 | CTSK (0.43) | EPHX2 | |
| SCHEMBL23992147 | 0.76 | SMN1; SMN2 (0.40) | KDM1ASMN1; SMN2EPHX1EPHX2CD274 | |
| SCHEMBL19872412 | 0.76 | CD274 (0.41) | KDM1ASMN1; SMN2EPHX1EPHX2CD274 | |
| SCHEMBL19856437 | 0.76 | EPHX1 (0.37) | KDM1ASMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL16891677 | 0.75 | CYP2C19 (0.56) | KDM1ASMN1; SMN2EPHX2ALDH1A1MAPK1 | |
| SCHEMBL15820963 | 0.74 | CHRNB2 (0.45) | SMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL25677360 | 0.74 | SMN1; SMN2 (0.48) | KDM1ASMN1; SMN2EPHX1EPHX2CD274 | |
| SCHEMBL25769751 | 0.74 | CD274 (0.39) | KDM1ASMN1; SMN2EPHX1EPHX2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024069448-A1 | SUBSTITUTED 1-ARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1-HETEROARYLAMINOCARBONYL-1'-HETEROARYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2024-04-04 | — | — | WO | disclosed |
| EP-4313968-A2 | SUBSTITUTED 1-ARYL-1'-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1'-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022237858-A1 | COMPOUND HAVING ANTI-TUMOR ACTIVITY AND USE THEREOF | 上海翊石医药科技有限公司 | 2022-11-17 | — | — | WO | disclosed |