Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MDM4 | O15151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27081455 | 0.94 | CASP3 (0.53) | CASP3TLR2KMT2AMDM4TP53 | |
| SCHEMBL16744142 | 0.86 | TLR2 (0.53) | CASP3TLR2MDM4TP53TNF | |
| SCHEMBL16744160 | 0.86 | TLR2 (0.53) | CASP3TLR2MDM4TP53TNF | |
| SCHEMBL13227979 | 0.84 | CASP3 (0.53) | CASP3TLR2KMT2AMDM4TP53 | |
| SCHEMBL119534 | 0.84 | CASP3 (0.60) | CASP3KMT2AMDM4TP53MDM2 | |
| SCHEMBL119338 | 0.84 | CASP3 (0.60) | CASP3KMT2AMDM4TP53MDM2 | |
| SCHEMBL16744154 | 0.83 | TLR2 (0.54) | CASP3TLR2MDM4TP53TNF | |
| SCHEMBL16744157 | 0.82 | TLR2 (0.56) | CASP3TLR2MDM4TP53TNF | |
| SCHEMBL16744155 | 0.82 | TLR2 (0.56) | CASP3TLR2MDM4TP53TNF | |
| SCHEMBL16744156 | 0.82 | TLR2 (0.56) | CASP3TLR2MDM4TP53TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4314015-A1 | INHIBITORS OF THE WNT SIGNALING PATHWAY AND USES THEREOF | Stichting VU (NL) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022203510-A1 | INHIBITORS OF THE WNT SIGNALING PATHWAY AND USES THEREOF | STICHTING VU (NL) | 2022-09-29 | — | — | WO | disclosed |
| EP-4063380-A1 | INHIBITORS OF THE WNT SIGNALING PATHWAY AND USES THEREOF | Stichting VU (NL) | 2022-09-28 | — | — | EP | disclosed |