Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30906007 | 1.00 | MAPK1 (0.46) | MAPK1IRAK4HDAC3HDAC1HDAC2 | |
| SCHEMBL4404049 | 0.90 | CA1 (0.45) | IRAK4CISD1CA12CA1CA2 | |
| SCHEMBL31436651 | 0.90 | CA1 (0.45) | IRAK4CISD1CA12CA1CA2 | |
| SCHEMBL2182279 | 0.88 | KCNH2 (0.48) | MAPK1IRAK4HDAC3HDAC1HDAC2 | |
| SCHEMBL21949044 | 0.87 | CA1 (0.52) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30883513 | 0.87 | CA1 (0.52) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL21949096 | 0.86 | CA1 (0.54) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL16873023 | 0.86 | IRAK4 (0.40) | IRAK4CISD1CA12CA1CA2 | |
| SCHEMBL21724991 | 0.86 | IRAK4 (0.47) | MAPK1IRAK4HDAC3HDAC1HDAC2 | |
| SCHEMBL30201761 | 0.86 | OPRK1 (0.46) | MAPK1IRAK4HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240300977-A1 | INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND USES THEREOF | INTELLIA THERAPEUTICS, INC. | 2024-09-12 | — | — | US | disclosed |
| EP-4323360-A1 | INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND USES THEREOF | Intellia Therapeutics, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221696-A1 | INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND USES THEREOF | INTELLIA THERAPEUTICS, INC. (US) | 2022-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240300977-A1 | INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND USES THEREOF | CHEK1, DCK, CHEK2 | MAPK1 128/4885IRAK4 1550/4885HDAC3 847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.