Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2711034 | 0.73 | HTT (0.50) | GAAALDH1A1LMNAHTTPKM | |
| SCHEMBL5572106 | 0.71 | GAA (0.44) | GAAALDH1A1LMNAHTTPKM | |
| SCHEMBL12469032 | 0.71 | KMT2A (0.67) | ALDH1A1LMNAHTTMAPK1POLB | |
| SCHEMBL23547606 | 0.68 | NPSR1 (0.44) | ALDH1A1LMNAHTTNPSR1NPC1 | |
| SCHEMBL17298876 | 0.67 | KDM4E (0.47) | ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL10222845 | 0.67 | NPC1 (0.49) | GAAALDH1A1LMNANPSR1NPC1 | |
| SCHEMBL31558401 | 0.67 | NPC1 (0.49) | GAAALDH1A1LMNANPSR1NPC1 | |
| SCHEMBL2710128 | 0.65 | NAMPT (0.46) | ALDH1A1ADORA2AMAPK1NPC1POLB | |
| SCHEMBL10767952 | 0.65 | GRM5 (0.52) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL306864 | 0.65 | BRD4 (0.43) | GAAALDH1A1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |