Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469032 | 0.84 | KMT2A (0.67) | HTTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL5572106 | 0.77 | GAA (0.44) | HTTLMNAALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL13164056 | 0.76 | KMT2A (0.63) | HTTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL12469175 | 0.75 | ALDH1A1 (0.59) | HTTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL2709904 | 0.73 | GAA (0.41) | HTTLMNAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL10095302 | 0.73 | VNN1 (0.62) | HTTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL31558401 | 0.72 | NPC1 (0.49) | LMNAALDH1A1KMT2ATDP1L3MBTL1 | |
| SCHEMBL10222845 | 0.72 | NPC1 (0.49) | LMNAALDH1A1KMT2ATDP1L3MBTL1 | |
| SCHEMBL16598445 | 0.71 | HTT (0.66) | HTTALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL10767952 | 0.70 | GRM5 (0.52) | ALDH1A1HPGDKDM4ENPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |