Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | ATM | Q13315 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.57 |
| ▸ | GBA1 | P04062 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21806091 | 0.88 | ALDH1A1 (0.52) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL12221079 | 0.87 | KMT2A (0.59) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL13521824 | 0.86 | ALDH1A1 (0.60) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL16573482 | 0.85 | ALDH1A1 (0.52) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL19158987 | 0.84 | KMT2A (0.54) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL17737793 | 0.82 | KMT2A (0.65) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL19423787 | 0.82 | PTPN2 (0.50) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL22473845 | 0.81 | KMT2A (0.64) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL20834029 | 0.81 | PTPN2 (0.49) | KMT2AMEN1MAPTALDH1A1ATM | |
| SCHEMBL16293207 | 0.81 | KMT2A (0.73) | KMT2AMEN1MAPTALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327830-A1 | A METHOD OF MODIFYING AN ORGANIC CYTOTOXIN FOR USE AS A PAYLOAD IN AN ANTIBODY-DRUG CONJUGATE AND MODIFIED ORGANIC CYTOTOXINS DERIVED THEREFROM | Simris Biologics GmbH (DE) | 2024-02-28 | — | — | EP | disclosed |