Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GCK | P35557 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9187790 | 0.90 | HDAC8 (0.67) | HDAC8SMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL26117094 | 0.86 | ATM (0.63) | HPGDKDM4EHIF1AMMP1NPC1 | |
| SCHEMBL9186841 | 0.85 | HDAC8 (0.60) | HDAC8SMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL27144496 | 0.85 | HIF1A (0.53) | HDAC8SMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL30759157 | 0.84 | MAPT (0.55) | HDAC8SMN1; SMN2ALDH1A1KDM4EGCK | |
| SCHEMBL27145544 | 0.83 | HPGD (0.54) | HDAC8SMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL30147470 | 0.80 | GCK (0.59) | HDAC8SMN1; SMN2HPGDGCKNPC1 | |
| SCHEMBL8782975 | 0.80 | HDAC8 (0.69) | HDAC8SMN1; SMN2ALDH1A1MMP1NPC1 | |
| SCHEMBL1222467 | 0.79 | MMP1 (0.74) | SMN1; SMN2HPGDALDH1A1KDM4EHIF1A | |
| SCHEMBL29762009 | 0.79 | AKR1C3 (0.77) | HDAC8KDM4ENPC1RAB9AAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260062443-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMA INC (US) | 2026-03-05 | — | — | US | disclosed |
| WO-2024044098-A2 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044098-A2 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260062443-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | C9, SSB, C1S | HDAC8 1441/4885SMN1; SMN2 21/4885HPGD 4023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.