Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18171776 | 0.73 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3MEN1 | |
| SCHEMBL13336494 | 0.71 | NPC1 (0.51) | DYRK1ATGFBR1RAB9ANPC1KDM4E | |
| SCHEMBL18732354 | 0.71 | DYRK1A (0.41) | DYRK1AKEAP1TGFBR1MEN1CYP1A2 | |
| SCHEMBL1542371 | 0.70 | CHEK1 (0.49) | DYRK1ATGFBR1KMT2ARAB9ANPC1 | |
| SCHEMBL21644144 | 0.70 | DYRK1A (0.59) | DYRK1AKEAP1TGFBR1MEN1CYP1A2 | |
| SCHEMBL11266549 | 0.70 | DYRK1A (0.40) | DYRK1AKEAP1TGFBR1MEN1CYP1A2 | |
| SCHEMBL20987177 | 0.70 | DYRK1A (0.53) | GABRA1GABRG2GABRB3GABRA3DYRK1A | |
| SCHEMBL24181926 | 0.70 | TGFBR1 (0.39) | DYRK1AKEAP1TGFBR1MEN1CYP1A2 | |
| SCHEMBL19368022 | 0.70 | TGFBR1 (0.37) | DYRK1AKEAP1TGFBR1MEN1KMT2A | |
| SCHEMBL30029521 | 0.69 | DYRK1A (0.41) | DYRK1AKEAP1TGFBR1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |