Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 5/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736185 | 0.86 | PIK3CG (0.80) | PIK3CGPIK3CAPIK3CBCDK5CDK2 | |
| SCHEMBL27115897 | 0.86 | PIK3CG (0.69) | PIK3CGPIK3CAPIK3CBCDK5CDK2 | |
| SCHEMBL4735972 | 0.82 | PIK3CG (0.78) | PIK3CGPIK3CAPIK3CBCDK5CDK2 | |
| SCHEMBL27116069 | 0.82 | PIK3CG (0.67) | PIK3CGPIK3CAPIK3CBCDK5CDK2 | |
| SCHEMBL27116528 | 0.80 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CBCDK5CDK2 | |
| SCHEMBL27116179 | 0.79 | PIK3CG (0.66) | PIK3CGPIK3CAPIK3CBCDK5CDK2 | |
| SCHEMBL7469928 | 0.79 | ABL1 (0.64) | PIK3CGPIK3CACDK5CDK2CDK4 | |
| SCHEMBL20004013 | 0.77 | PIK3CG (0.56) | PIK3CGPIK3CAPIK3CBCDK5CDK2 | |
| SCHEMBL27115762 | 0.77 | CDK2 (0.58) | PIK3CGPIK3CAPIK3CBCDK5CDK2 | |
| SCHEMBL27114966 | 0.77 | PIK3CA (0.49) | PIK3CGPIK3CAPIK3CBCDK5CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |